Biopolis Dresden Imaging Platform

Tamoxifen-independent recombination in the RIP-CreER mouse.

Liu Y, Suckale J, Masjkur J, Magro MG, Steffen A, Anastassiadis K, Solimena M

The inducible Cre-lox system is a valuable tool to study gene function in a spatial and time restricted fashion in mouse models. This strategy relies on the limited background activity of the modified Cre recombinase (CreER) in the absence of its inducer, the competitive estrogen receptor ligand, tamoxifen. The RIP-CreER mouse (Tg (Ins2-cre/Esr1) 1Dam) is among the few available ?-cell specific CreER mouse lines and thus it has been often used to manipulate gene expression in the insulin-producing cells of the endocrine pancreas.

Fig.3 taken from Liu et al, 2010.
  • PLoS ONE 2010 Oct 22;5(10):e13533
  • 2010
  • Medical Biology
  • 21063464
  • PubMed

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