Biopolis Dresden Imaging Platform

Cadmium disorganises the scaffolding of gap and tight junction proteins in the hepatic cell line WIF B9.

Boucherie S, Decaens C, Verbavatz JM, Grosse B, Erard M, Merola F, Cassio D, Combettes L

Hepatocytes, which perform the main functions of the liver, are particularly vulnerable to toxic agents such as cadmium, an environmental pollutant. To identify the molecular targets for cadmium in hepatocytes, we have studied the effects of CdCl2 on the hybrid cell line WIF-B9 that exhibits stable structural and functional hepatocytic polarity.

Fig.6 taken from Boucherie et al, 2013.
  • Biol. Cell 2013 Dec 11;105(12):561-75
  • 2013
  • Cell Biology
  • 24117459
  • PubMed

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